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Author(s): Smita Singh a, Kunal Arora b, Vishal Khandelwal c, Mukesh Kumar d, Kapil Sachan e, Pranjal Kumar Singh f

Email(s): pranjal.pharmacy@gmail.com

Address:

    a Department of Pharmacy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Old textile mill compound, Modinagar, Ghaziabad
    b Department of Pharmacy, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
    c Department of Biotechnology, GLA University, Mathura, Uttar Pradesh, India
    d Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut
    e Department of Pharmacy, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, Uttar Pradesh, India
    f Department of Pharmacy, Kalka Institute for Research and Advanced Studies, Meerut, Uttar Pradesh, India

Published In:   Volume - 2,      Issue - 1,     Year - 2025

DOI: 10.5281/zenodo.16015866  

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ABSTRACT:
Current drug delivery systems are based on the idea that the medication should be delivered precise time frame to achieve a therapeutic impact and then released in a controlled manner to keep that effect going for a long time. This review article aims to present the deepest knowledge about bilayer tablet technology, which is a new system of drug delivery. The bilayer tablet method has shown promising results in the management of inflammatory disorders, cardiovascular disease, and diabetes. To effectively treat an illness, bilayer tablets integrate two or more pharmaceuticals, which can be either the same or different, into a single dosage form. This review aims to shed light on the difficulties encountered while making bilayer tablets and to offer suggestions for overcoming these difficulties. This review article aims to shed light on a number of contemporary characterization techniques for bilayer tablet technology and their respective methods to parameter analysis. This review is novel in describing the recent technological advances in bilayer tablet development, such as floating drug delivery systems, mucoadhesive methods, and programmable release systems. In this review, critical manufacturing process issues, such as interfacial bonding problems, are emphasized and potential solutions for achieving mechanical and functional stability could be offered. Moreover, new methods and instrumentation for bilayer tablet characterization are advanced to maximize their therapeutic benefits.

Cite this article:
Singh S, Arora K, Khandelwal V, Kumar M, Sachan K, Singh PK. Bilayer tablets in controlled drug delivery: a comprehensive review of modern formulation strategies. Probecell Science. 2025;2(1):20–32.DOI: https://doi.org/10.5281/zenodo.16015866


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