Recent Advancement in Drug Development for Intranasal Drug Delivery System

M. Kranti Kumar a; Khemkaran Ahirwar b; Sheetal Mishra c

doi:10.5281/zenodo.13767525

editor.probsci@gmail.com

Probecell Science

Open Access | E-ISSN: 3049-1584

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Recent Advancement in Drug Development for Intranasal Drug Delivery System

Author(s): M. Kranti Kumar a, Khemkaran Ahirwar b, Sheetal Mishra c

Email(s): mkrantikumar13@gmail.com

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Published In: Volume - 1, Issue - 2, Year - 2024

DOI: 10.5281/zenodo.13767525

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ABSTRACT:
A growing number of researchers are interested in exploring the possibility of nasal medication delivery as an alternate route of administration for vaccines and biomolecules like proteins, peptides, and non-peptide pills. As a legitimate method of treatment, intranasal therapy has gained acceptance within the ayurvedic medical system. Medications that undergo substantial degradation in the gastrointestinal tract or are metabolised by the first pass effect in the liver when taken orally are often more stable when administered via the nasal route. A long-term alternative to parenteral therapy, the nasal route has its uses in both acute and chronic settings. The nasal mucosa is very permeable and has a high vascularization rate, which allows for quick absorption and action beginning. Since the medication enters the systemic circulation straight from the nasal route, it is not only useful for local treatments but also for systemic therapy. When administering tiny molecules via the nasal route, absorption is good; when administering large molecules, absorption promoters can improve absorption even further. This article provides a high-level summary of intranasal medication administration, covering topics such as methods to increase bioavailability and elements influencing nasal absorption.

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Cite this article:
Kumar MK, Ahirwar K, Mishra S. Recent Advancement in Drug Development for Intranasal Drug Delivery System. Prob. Sci., 2024;1(2):1-19.DOI: https://doi.org/10.5281/zenodo.13767525

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